山梨医科大学雑誌　第10巻3号　085-090(1995)

Effect of New Type β-blocker, Tilisolol Hydrochloride,
on the Cardiovascular System in Healthy Young Volunteers

Atsushi SUGIYAMA, Nobuo HOMMA,
Hidenori AKAIKE, Eiki MIZUTANI, and Keitaro HASHIMOTO

Abstract: The cardiovascular prolfle of tilisolol hydrochloride, a new type β-blocking agent that induces vasorelaxation after opening the potassium channels, was examined and the results were compared with those of metoprolol and carteolol. Fifty-seven healthy young volunteers were entered into the current double-blind, placebo-controlled study. The double protocol of the Master's test was used for the exercise. Tilisolol (10 mg, p.o.) decreased pre- and post-exercise systolic blood pressure, pulse rate and double-product within 2 hr after the drug administration, and it also reduced the increment of double-product by exercise at 1 hr as well as at 2 hr, which could reflect myocardial oxygen consumption. Metoprolol (40 mg, p.o.) and carteolol (5 mg, p.o.) showed trends similar to those observed by tilisolol. Since tilisolol is well-tolerated and possesses a cardiovascular profile similar to those of clinically well-established β-blockers, it may become a clinically useful drug.

Key words: tilisolol, metoprolol, carteolol, β-blocker, myocardial oxygen consumption




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