山梨医科大学雑誌　第12巻2号　035-043(1997)

＜総説＞ストレス応答における視床下部インターロイキン-1の役割

神庭重信

抄　録：脳内ストレス応答機構として良く知られているものに，視床下部におけるコルチコトロピン放出ホルモン（CRH）の放出と中枢神経内でのカテコラミンの代謝回転の亢進がある。これらのストレス応答に，インターロイキン-1（IL-1）などのサイトカインがさらに上位で関与することがわかってきた。本稿では，1) ストレス応答機構とうつ病との密接な関係を紹介し，2) IL-1のCRH放出やカテコラミン代謝回転に与える作用についてレビューし，3) うつ病の成因におけるIL-1の関与の可能性を推論した。

キーワード　ストレス，うつ病，インターロイキン-1，コルチコトロピン放出ホルモン，カテコラミン



Role of Central Interleukin-1 in Stress Responses

Shigenobu Kanba

Recently, the central roles of interleukin-1 (IL-1) in stress responses have been attracting attention. Stress responses have been characterized as central neurohormonal changes, as well as behavioral and physiological changes. Administration of IL-1 has been shown to induce effects comparable to stress-induced changes. IL-1 gcts in the hypothalamus to enhance release of monoamines and corticotropin-releasing hormone (CRH). We showed that IL-1 and IL-1 receptor antagonist in the hypothalamus are involved in the stress response, such as stfess-induced activation of monoamine release and tht HPA axis. In depressive disorder, monoamine release is generally believed to be impaired, and hyperfunction of the hypothalamo-pituitary-adrenal axis which results in dexamethasone non-suppression is consistently observed. Taking these findings together, we deemed it worthwhile to investigate these cytokines in mood disorders, in which involvement of genetic factors has also been strongly suggested. There was a significant association between alleles of the lL-1 β gene and overall mood disorders, and a stronger association between these alleles and unipofar disorder. Our results indicate that IL-1 β may play an important role in the etiology of depressive disorder.

Key words: Interleukin-1, interleukin-1 receptor antagonist, stress, depression



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