山梨医科大学雑誌　第14巻2号　059-066(1999)

＜原著＞人間ドックデータと眼圧値との関連

雨宮哲士，関希和子，笹森典雄，塚原重雄

抄 録：対象，方法：平成9年に牧田総合病院人間ドックを受診した1,951名（男1,676名，女275名）をサンプルとして眼圧，年齢，収縮期及び拡張期血圧，糖負荷検査結果，身長，体重のデータを集計し，眼圧値とその他のデータとの相関および偏相関を算出した。また，検査結果から高血圧，糖尿病，肥満とそれぞれの境界群を抽出し，正常群と眼圧の平均値を比較した。眼圧は右眼の値を使用，肥満判定にはBMI（body mass index）を用いた。
結果：眼圧との相関係数は年齢−0.140，収縮期血圧0.183，拡張期血圧0.203，空腹時血糖0.133，2時間値0.097，BMI 0.122（全てp＜0.0001:Fisherのrのz変換）で拡張期血圧との相関がもっとも強かった。眼圧と年齢，拡張期血圧，空腹時血糖，BMIとの偏相関係数はそれぞれ−0.153，0.176，0.125，0.049だった。各群間での眼圧平均値の比較では高血圧群，境界型群は正常群に対して有意に高値で，糖尿病群，境界群，正常群の順に高値で各群間に有意差が認められた。また，肥満群は他より高値で，やせ群は他群より低値。普通群と過体重群には差は無かった（post-hoc 検定，FisherのPLSDによる）。高眼圧（＞20mmHg）となるオッズ比は高血圧が10.5倍（p＝0.005），糖尿病が15.0倍（p＝0.004）で有意だった。（ロジスティック回帰解析，Wald検定）結論：高血圧，糖尿病とそれらの境界群及び肥満群は正常に対して眼圧の平均値が有意に高値である。

キーワード　眼圧，高血圧，糖尿病，BMI，加齢



RELATION BETWEEN INTRAOCULAR PRESSURE
AND GENERAL DATA IN OUR HEALTH PLANNING CENTER

Tetsuji AMEMIYA, Kiwako SEKI, Norio SASAMORI and Shigeo Tsukahara

Subjects and methods: 1,951 people (1,676 males, 275 females) who were examined in Makita General Hospital Health Planning Center in 1997 were selected as sample population. Intraocular pressure (IOP), age, systolic and diastolic blood pressure, glucose tolerance test results, height, and weight were statistically analyzed. Correlation coefficients and partial correlation between IOP and the other parameters were calculated. They were divided into the following groups from the inspected results: health, hypertension, diabetes mellitus, obesity, and respective boundary groups. The means of IOP of these groups were compared with the mean of IOP of the healthy group.
Result: Correlation coefficients between IOP and age, systolic and diastolic blood pressure, FBS, glucose tolerance test results (2hr), and BMI were −0.140, 0.183, 0.203, 0.133, 0.097, and 0.122, respectively (p＜0.0001: Fisher's r to z test). Partial correlation coefficients between IOP and age, diastolic pressure, FBS, and BMI were −0.153, 0.176, 0.125, and 0.049, respectively. The means of IOP of the groups with hypertension, diabetes, and ther respective boundary groups were higher than those of the hralthy, group. As for the obesity group, IOP was higher than in the hralthy group (post-hoc; Fisher's PLSD). The risk factors of ocular hypertension (＞20mmHg) were hypertension (odds ratio＝10.5, p＝0.005) and diabetes (odds ratio＝15.0 p＝0.004) (logistic regression analysis, Walt test).
Conclusion: IOP of the groups with hypertension and diabetes, their respective boundary groups, and the obesity group were higher than those of the healthy group.

Key words: intraocular pressure, hypertension, diabetic mellitus, body mass index, aging



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