山梨医科大学雑誌　第14巻3号　077-082(1999)

Fixed Schedule for in vitro Fertilization and Embryo Transfer:
Comparison of Outcome between the Short
and the Long Protocol

Tsuyoshi KASAI and Kazuhiko HOSHI

Abstract: This study sought to evaluate whether a short or long protocol would be preferable for simplification of a fixed-schedule for in vitro fertilization and embryo transfer (IVF-ET) program without negatively affecting the pregnancy rate per cycle.　All women were allocated, according to the ovarian stimulation protocol, into two groups.　In Group 1 for the short protocol (41 occasions), the patients were treated with human menopausal gonadotropin (hMG) before pituitary desensitization using buserelin from cycle day 1.　In the Group 2 for the long protocol (106 occasions), the patients received hMG after pituitary desensitization achieved with buserelin.　The day and time of ovum pickup (OPU) was fixed as a Wednesday.　Ovarian stimulation was started on Monday, 10 days before the day of OPU, with a daily dose of 225 IU/hMG for the following 7 days.　Ovulation was induced with human chorionic gonadotropin (hCG) on Tuesday, and OPU was performed on Wednesday; ET was carried out on Friday.　No significant differences were found between the two groups in the incidence of canceled cycles [group 1: 7.3 ％(3/41), group 2: 2.8 ％(3/106)], mean number of oocytes recovered (6.4 ±4.0, 5.8 ±5.1), the fertilization rate [40.6 ％(106/261), 44.3 ％(272/614)], or the pregnancy rate per cycle [19.5 ％(8/41), 18.9 ％(20/106)].　These findings indicate that treatment with buserelin/hMG/hCG with either a short or long protocol is useful for a fixed-schedule IVF-ET program.

Key words: Fixed schedule, In vitro fertilization and embryo transfer (IVF-ET), Gonadotropin releasing hormone agonist (GnRHa), Human menopausal gonadotropin (hMG), Human chorionic gonadotropin (hCG)




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