山梨医科大学雑誌　第15巻4号　091-096(2000)

Vascular Endothelial Growth Factor Receptor, Flk-1,
Localization in Purkinje Cell Processes

Hideho UEDA and Shinichi OHNO

Abstract: Vascular endothelial growth factor (VEGF) and VEGF receptors are implicated in angiogenesis or vasculogenesis in many tissues under both developmental and pathological conditions. Recent studies, however, have suggested that VEGF functions in non-vascular cells. To address whether VEGF receptor, Flk-1 or Flt-1, is expressed in the cerebellum under physiological conditions, we immunohistochemically examined the rat cerebellum at postnatal day 10 (P10), P15 and in adulthood. Here, we demonstrate that rat Purkinje cells show Flk-1, but not Flt-1, expression in dendrites, cell bodies and axons at all stages examined. Its localization seemed to be in the cytoplasm or axoplasm, and not restricted to the cell membrane. These data suggest that Flk-1 is constitutively expressed in rat cerebellar Purkinje cells, although its physiological function is totally unknown at present.

Key words: Vascular endothelial growth factor (VEGF), Flk-1, Cerebellum, Purkinje cell, Immuno-histochemistry




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