山梨医科大学雑誌　第16巻1号　009-014(2001)

＜Original Article＞Fibroblast Growth Factor-2 Stimulates New Bone Formation on Allografts of Demineralized Bone Matrix in Segmental Bone Defects in Rabbits

Tetsuo HAGINO, Yoshiki HAMADA and Takeshi AMEMIYA

Abstract: We studied whether fibroblast growth factor-2 stimulates new bone formation on allografts of powdery demineralized bone matrix (DBM) in segmental bone defects of Japanese white rabbit ulnae. A 1.5 cm bone defect was created on the distal 1/3 of the rabbit ulnar diaphysis and grafted with a 50 mg DBM that had been saturated with 0, 20, or 200 mg of recombinant human fibroblast growth factor-2 (rhFGF-2) in 200 ml of saline solution. As for new bone formation at the bone defect, radiographic film 3 weeks after surgery revealed marked calcification to be more pronounced in the group with 200 mg of rhFGF-2 than in the group with DBM alone. Histologically, the use of 200 mg of rhFGF-2 resulted in abundant new bone formation as if to bridge both end-sides of the resected part.FGF-2 was found to be effective for early new bone formation in DBM grafting to the bone defect.

Key words: Fibroblast growth factor-2, Demineralized bone matrix, Bone formation, Segmental bone defects, Rabbit




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