山梨医科大学雑誌　第16巻1号　015-024(2001)

＜Original Article＞Lipo-Prostaglandin E1 Improves Heart Rate Variability in Patients with Type 2 Diabetes Mellitus

Hiromichi SHIMODA, Masato TAWATA, Ken UMETANI, Hideo SHINDO, Kaoru AIDA and Toshimasa ONAYA

Abstract: The effect of lipo-prostaglandin E1 on heart rate variability (HRV) was investigated in 30 hospitalized patients with type 2 diabetes mellitus. After evaluating HRV, patients were divided into Control and Treatment groups. The Control group received the continuation of glycemic control, while the Treatment group received an infusion of 10 mg lipo-prostaglandin E1/day for seven days in addition to glycemic control. HRV was re-evaluated seven days after the first examination in both groups. The parameters are ; 1) time domain indices consisting of standard deviation of all normal R-R intervals, standard deviation of the means of all 5-min segments of normal R-R intervals, mean of the standard deviation of all normal R-R intervals for all 5-min segments ; 2) frequency domain indices consisting of very low frequency power, low frequency power, high frequency power and total frequency power. There was no significant change in HRV indices between the two examinations in the Control group, whereas there was a significant increase in seven HRV indices between the two examinations in the Treatment group. The present study suggests that lipo-prostaglandin E1 improves autonomic function in patients with type 2 diabetes mellitus.

Key words: Diabetic autonomic neuropathy, Lipo-prostaglandin E1, Heart rate variability, Time and spectral analyses, Parasympathetic activity




本文は、編集委員会の意向によりインターネットには公開しておりません。図書館等でご覧ください。

Texts are not availavle on Internet.



目次・Contentsに戻る