山梨医科学雑誌　第18巻2号　033-036(2003)

＜Original Article＞
Effects of Clinically Available Blended Herbal Medicines (Kampo
Extracts) on the Phosphodiesterase Activity in Rat Hearts

Yoshiki SAEGUSA, Atsushi SUGIYAMA and Keitaro HASHIMOTO

Abstract: We examined the effects of clinically available Kampo medicines; Kakkon-to (Formula puerariae), Boi-ogi-to (Formula astragali et sinomenii), Chorei-to (Formula polypori) and Tsu-do-san(Pulvis purgtionis sanguinolentiae), on phosphodiesterase (PDE) activity in the rat heart. PDE activity was estimated by measuring the cyclic AMP hydrolyzing speed using the enzymatic fluorometric assay technique. Kakkon-to, Boi-ogi-to and Tsu-do-san decreased PDE activity in a concentration-related manner, while Chorei-to hardly affected it. These results suggest that recently demonstrated cardiotonic effects of Kakkon-to, Boi-ogi-to and Tsu-do-san may be exerted in part via their PDE inhibitory action.

Key words: phosphodiesterase, herbal medicines, Kampo, cardiotonic effects




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