山梨医科大学雑誌　第2巻4号　125-135(1987)

＜総説＞緑内障薬物療法とCOMPLIANCE

塚原重雄




Compliance in the Medical Treatment of Primary Open Angle Glaucoma
- newly designed medication monitor -

Shigeo Tsukahara

Compliance is defined as "the patient is taking the drug as directed by doctor". The direction given by doctors includes general advice, prescribed medication, and schedule appointment. However, in this paper the second subject is dealt with glaucoma treatment. Patient compliance is a major problem in the treatment in primary open angle glaucoma, which causes no pain and disability to encourage the patient to take the treatment. Moreover, this disease requires long-term treatment and follow-up for life. Therefore, it is essential that the drugs are taken regularly to prevent further visual damage. The aim of treatment in primary open angle glaucoma is to maintain good visual function throughout the patient's life. Physician does not know whether a lack of patient compliance or a lack of drug effectiveness is the cause of deterioration in the disease. Therefore, an objective test to measure compliance is necessary for the treatment of glaucoma patients. To achieve this aim the doctor must regularly check whether the patient is complying with the treatment or not. Several methods have been used to measure compliance, such as interviewing patients, counting remaining pills, measurement of residual volume for the drugs, or measurement of metabolites in urine or blood, and the use of an automatic medication monitor. In these methods the medication monitor gives the most precise and objective information on compliance. The purpose of the present study was to describe the results which our newly designed medication monitors were applied in the medical treatment of primary open angle glaucoma (POAG) patients and to improve methods to measure medication behavior, in order to obtain accurate and reliable information on the patterns of drug-taking in primary open angle glaucoma patients.




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