山梨医科学雑誌　第21巻3号　053-058(2006)

＜Original Article＞
Usefulness of the 50-g Glucose Challenge Test for Screening of Patients
with Gestational Diabetes Mellitus and an Analysis of the Timing of
Administration of the Test

Keiko KOHNO, Kazuhiko HOSHI, Motoi TAKIZAWA,
Takashi KANEKO, and Shuji HIRATA

Abstract: Objective We determined whether performing the glucose challenge test (GCT) during early pregnancy is an effective screening method for gestational diabetes mellitus (GDM). Methods The subjects included 201 pregnant Japanese women on whom a GCT was performed in early and mid-pregnancy, and an oral glucose tolerance test (OGTT) was performed 2D3 weeks after the GCT. The cut-off level for GCT determination was set at 130 mg/dl. The results of the OGTT that indicated the GDM type were displayed as the OGDM pattern.O The present study identified the cases as GDM only if they exhibited a GDM pattern based on the results of OGTT conducted during midpregnancy.
Results Based on the results of the GCT with respect to GDM detection during mid-pregnancy, the sensitivity and specificity of the test were found to be 100% (3/3) and 88% (174/198), respectively. During early pregnancy, the sensitivity and specificity of GCT with respect to detection of cases exhibiting a GDM pattern in an OGTT were 63% (5/8) and 84% (63/193), respectively. The 3 cases
that were diagnosed as GDM during mid-pregnancy were found to be GCT-positive during early pregnancy, and a GDM pattern was observed based on the results of an OGTT that was conducted during early pregnancy. Thus, the sensitivity and specificity of GCT during early pregnancy for GDM-detection during mid-pregnancy were 100% (3/3) and 84% (166/198), respectively. Discussion GCT performed during early pregnancy is an effective screening method for detecting
GDM during mid-pregnancy.

Key words : Gestational diabetes mellitus, Glucose challenge test, Oral glucose tolerance test




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