山梨医科大学雑誌　第3巻1号　015-020(1998)

Comparison of Effects of Irradiation with Continuous Wave
Nd-YAG and Argon-Ion Laser, and Pulsed Ultraviolet
XeCl-Excimer Laser on the Human Aortic Wall

Masaru Iwasaki, Masahiro Kobayashi, Kihachiro Kamiya,
Shigeo Akimoto, Yutaka Takayama, and Akira Ueno

Abstract: To compare the etfects of continuous wave and pulsed laser irradiation on vessel walls, fourty-five human cadaver aortic segments were irradlated with either an Nd-YAG, Argon-ion, or XeCl-excimer laser through a quartz fiber. All segmnents were immersed in saline sofution, exposed to laser radiation with variations in power and duration of irradiation, and examined macroscopically and microscopically. In continuous wave mode lasers, the Nd-YAG laser produced a large, ragged crater surrounded by extensive thermal injury. The crater produced by the Argon-ion laser irradiation was somewhat sharp compared to that produced by the Nd-YAG laser, however, thermal injury around the crater was also observed. In contrast, the pulsed XeCl-excimer laser-irradiated tissue showed small craters with no visible thermal damage. The edge of the crater was smooth, and the microscopic examination revealed minimal thermal injury around the margin of the crater. These results suggest that the pulsed XeCl-excimer laser is more suitable for laser angiopalsty than conventional continuous wave lasers. However, as we were unable to penetrate even the inner layer of the aortic wall, the development of a fibroptic systm capable of transmitting the higher power of excimer lase energy will be needed.

Key words: Argon-ion laser, Excimer laser, Laser angioplasty, Nd-YAG laser, Occlusive arterial disease



ヒト大動脈に対する Nd-YAG，アルゴン・レーザーと，
エキシマ・レーザーの照射効果の比較

岩崎　甫，小林正洋，神谷喜八郎，
秋元滋夫，高山　豊，上野　明





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