山梨医科大学雑誌　第3巻4号　137-140(1988)

Effects of some Kampo Medicines on Sorbitol Dehydrogenase

Kaoru AIDA, Masato TAWATA, Hideo SFHNDO, and TOoshimasa ONAYA

Abstract: We reported previously that some kampo medicines have aldose reductase (AR) inhibiting activities. Then, we studied the effects of these drugs on sorbitol dehydrogenase (SDH) from rat lenses or sheep liver. SDH is another enzyme constituting the polyol pathway. An 0.1 mg/ml concentration of Hatimi-zio-gan slightly stimulated rat lens SDH by 11.7%, and the same concentration of Keihi inhibited it by 34.7%. Keisi-ka-zyutubu-to, Sokei-kakketu-to, Gosya-zinki-gan, Shakuyaku, Kanzo, Sojutsu, Kakobushimatsu, Taiso and shokyo had no etfect on SDH activities. Nevertheles, since these kampo medicines inhibit AR activities, kampo medicines reduce the sorbitol content in tissues by inhibiting AR and not by stimulating SDH.

Key words: sorbitol dehydrogenase, Aldose reductase, Kampo medicines, polyol pathway, Diabetic complications




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