山梨医科大学雑誌　第4巻4号　167-172(1989)

Changes in Serum High-Density Lipoprotein Subfraction
Cholesterol in the First Four Weeks of Life

Kohtaro ASAYAMA and Kiyohiko KATO

ABSTRACT: We evaluated the developmental change in serum total cholesterol and cholesterol concentration in high-density lipoprotein subfractions (HDL2-C and HDL3-C) during the neonatal period. Eighteen term newborn infants without any major perinatal complications eere venipunctured before the initial fceding, and at the second and fourth weeks of life. HDL2 and HDL3 were separated by the micromethod for combined precipitation-ultracentrifugation. To measure the paired samples from a single subject in one assay, we verified that the concentrations of HDL2-C and HDL3-C were unaffected by 4 weeks of storage when the sera were kept at -70℃. The level of (total - HDL) cholesterol increased markedly in the first week of life and was unaltered thereafter. On the other hand, the HDL-C level was unaltered in the first week and then increased at 4 weeks of age. The HDL3-C was increased at 1 week, but returned toward the initial level at 4 weeks. The overall increase in HDL-C was less than that in the rest of the fractions. Thus, a LDL predominant pattern was established during the neonatal period. These changes in the HDL3-C are unique to newborns, because changes, in response to nutritional intervention, occur solely in the HDL2 fraction in later life. These results suggest the existence of non-nutritional factors related to the evolution of lipoproteins in the neonatal period.

Key words: lipoproteins, lipid metabolism, high-density lipoproteins, cholesterol, newborn infant.




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