山梨医科大学雑誌　第4巻4号　195-199(1989)

A Case of Renal Cell Carcinoma with Lung Metastases Treated
with Adoptive Immunotherapy

Noboru YABUSAKI, Hideki KOMATSU, Akira UEN, and Kachio TASAKA

Abstract: A patient with renal cancer and lung metastases who was treated with lymphokine-activated killer cells (LAK cells) is reported. A 52-year-old male was admitted because of asymptomatic hematuria in August 1986. Computed tomography showed a large renal tumor on the right side and the chest X-ray film revealed multiple lung metastases. Right nephrectomy was performed in September 1986. Histologically, the tumor was diagnosed as a renal cell carcinoma. Infusion of vinblastin via the bronchial arteries had no effect on the metastatic lesions. LAK therapy was started in Apri1 1987. Peripheral blood lymphocytes were purified from the patient's leukocytes collected by leukapheresis and then cultured at a concentration of 1-2×10^6 cells/ml with 3-6 U/ml of human recombinant interleukin-2 in complete RPMI 1640 medium for 3-8 days. In the initial two treatments, LAK cells were infused intravenously, but from the third treatment they were infused via the bronchial arteries. The number of LAK cells infused was 4×10^8-3.2×10^9 per treatment and 16.1×10^9 in a total of 11 treatments. LAK therapy was stopped because of a toxic reaction which developed during the 11th infusion. The cause of this reaction was not obvious, but it was apparently an allergic mechanism. During LAK therapy the metastatic lesions slightly increased in size.

Key words: lymphokine-activated killer cell, interleukin-2, adoptive immunotherapy, lung metastases from renal cancer, plasma exchange




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