山梨医科大学雑誌　第5巻1号　069-074(1990)

Insulin Resistance Type A syndrome in a 12-year-old Girl

Norihiko YOKOMORI, Masato TAWATA, Kaoru AIDA, Zentoshi ABEORI,
and Toshimasa ONAYA

Abstract: An obese 12-year-old girl with acanthosis nigricans was referred to the hospital because of hyperinsulinemia. She was 156 cm tall and her body weight was 67.5 kg. Physical examination revealed that she had acanthosis nigricans in the neck, axillary and inguinal regions. She also had hirsutism over the extremities. Endocrinological data showed mild elevations of plasma luteinizing hormone, testosterone and androstenedione and urinafy testosterone. A signifiecnt reduction of 125I-insulin binding to her red blood cells was observed. Serum anti-insulin antibodids or anti-insulin receptor antibodies were not detected. The Clinical and laboratory data suggested that this patient had a syndrome known as Type A insulin resistance.

Key words: Insulin Resistance Type A, Acanthosis Nigricans, Obesity, Hirsutism




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