山梨医科大学雑誌　第5巻2号　093-095(1990)

Age-Related Changes in the Spontaneous Motor Activity during
the Dark Phase in the Male Mouse

Age-Related Changes in the Spontaneous Motor Activity during the Dark Phase in the Male Mouse

Abstract: Spontaneous motor activity was studied in first generation (F1) hybrid C57BL/6 x C3H male mice at the ages of 6, 18 and 36 months. Activity was recorded for 10 consecutive hours during the dark phase, using a capacitance-induction motility monitor. The recordings were taken simultaneously at 2 levels of sensitivity; total activity (T) for the fine and gross movements and large activity (L) for the gross movements. The data were measured in 1 hour intervals and then stored on discs for micro-computer analysis. The T activity decreased with age. Changes in the mean hourly scores of T and L activity with time during the 10 hour dark phase differed among the 3 age groups. The results suggest that spontaneous motor activity during the dark phase is a useful parameter of changes in the motor function in aged mice.

Key words: spontaneous motor activity, mouse, aging.




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