山梨医科大学雑誌　第5巻2号　097-103(1990)

Tumor Necrosis Factor Stimulates Acetyltransferase
Activity of Human Neutrophils

Yukio 0ZAKI,Toshio 0YAMA, Yuki MATSUMOTO, and Shoji KUME

Abstract: Of the five cytokines tested (tumor necrosis factor, interleukin 1, colony-stimulating factor, interferon alpha, beta, and gamma), only tumor necrosis factor (TNF) showed a potent stimulatory effect on acetyltransferase activity of human neutrophils. Acetyltransforase is a key enzyme for the production of platelet-activating factor. This potentiating effect of TNF was time- and dose-dependent and was effectively blocked by TNF antiserum. Intracellular Ca++ elevation, protein kinase C activation, and arachidonic acid metabolites appeared not to be involved in the TNF-induced potentiation of the acetyltransferase activity in neutrophils.

Key words: tumor necrosis factor, acetyltransferase, platelet-activating factor, neutrophils, cytokines




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