山梨医科大学雑誌　第5巻2号　105-110(1990)

Metabolism of High Density Lipoprotein Cholesterol in Kawasaki
Disease: Multiple Regression Analysis

Kohtaro ASAYAMA and Kiyohiko KATO

Abstract: The relationship between the abnormalities in lipoprotein metabolism and protein metabolism, and its relevance to increased oxidative stress was evaluated in patients with Kawasaki disease. With special reference to high density lipoprotein cholesterol (HDL-C), multiple regression analysis was performed. Twenty-five children, 14 males and 11 females, with Kawasaki disease were tested in the acute phase of the disease. Eighteen children, 15 males and 3 females, served as controls. Serum triglyceride level was higher in the patients than in the controls. The total cholesterol level in the patients was similar to the controls, whereas both HDL2-C and HDL3-C were markedly decreased in the patients. Serum levels of apolipoprotein A1, A2, prealbumin and retinol-binding protein, and the activities of postheparin plasma lipoprotein lipase and hepatic triglyceride lipase were also markedly decreased in the patients. On the other hand, serum lipid peroxide level was increased in the patients. The results of the multiple regression analysis suggest that, the decreased availability of apolipoproteins is the primary determinant of the reduction of cholesterol in both HDL subfractions, and that oxidative vascular endothelial cell injury,leading to a loss of lipoprotein lipase and, in turn, hypertriglyceridemia, significantly contributes to the decrease in serum level of HDL-C in patients with Kawasaki disease.

Key words: Kawasaki disease, high density lipoprotein, lipid peroxide, lipoprotein lipase, rapid turnover protein




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