山梨医科大学雑誌　第6巻1号　031-037(1991)

Sister Chromatid Exchange (SCE) Frequency in Human and Simian
Lymphoid Cell Lines Infected with Simian Retroviruses Closely Related
to Human T-cell Leukemia Virus Type-1

Kumiko IIJIMA, Atsumi TSUJIMOTO, Hajime TSUJIMOTO, Masanori HAYAMI, Makoto HIGURASHI,
and Munehiro HIRAYAMA

Abstract: Sister chromatid exchange (SCE) frequencies were examined on 4 simian lymphoid cell lines producing simian retroviruses closely related to human T-cellleukemia virus type-1 and 6 human lymphoid cells immortalized by these simian viruses. The frequencies of SCE in both simian and human lymphoid cell lines were higher than those in normal cultured simian and/or human lymphocytes.
We also observed the change of SCE frequencies in human cell lines immortalized by STLV at several passage levels. At an early passage level the frequency of SCE in these human cell lines was already higher than that in normal lymphocytes culture. This rise in SCE frequency did not change significantly during the observation period for 180 days.
From these findings we concluded that human lymphocytes were infected with STLV as simian lymphocytes, and that STLV caused same DNA damage in human lymphocytes as in simian lymphocytes. These phenomena induced by the retrovirus infections may correlate with leukemogenesis .

Key words: Simian T-cell leukemia virus (STLV), Adult T-cellleukemia (ATL), Sister chromatid exchange (SCE), Human T-cell leukemia virus type-1 (HTLV-1), Lymphoid cell line




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