山梨医科大学雑誌　第6巻3号　127-135(1991)

Biological Monitoring of Exposure to Organic Solvent Vapors
I. A Physiological Simulation Model of m-Xylene
Pharmacokinetics in Man

Takashi KANEKO, Kazushi ENDOH, and Akio SATO

Abstract: A physiological pharmacokinetic model of the transfer of organic solvents in the human body was developed. The model was comprised of seven compartments, i.e., lungs, vessel-rich tissues, vessel-poor tissues, muscles, fat tissues, gastrointestinal tissues, and liver, each being connected to the others by blood flow. The transfer of organic solvents was expressed by simultanfous differential equations, which were then solved numerically by a personal computer using a slmple spreadsheet program. m-Xylene was used as the representative organic solvent. Partition coefficients of m-xylene between blood and air and between body tissue and blood were experimentally determined with blood and tissues of rats. The metabolic constants (Vmax and Km) of m-xylene metabolism and the excretion rate constant of m-methyl hippuric acid (m-MHA) were also determined using rats. These animal data were scaled up and used as the simulation parameters for humans. The results of the simulation of human exposure to m-xylene were essentially in agreement with human experimental data.

Key words: Physiologically based pharmacokinetic model, m-Xylene, m-Methyl hippuric acid, Michaelis-Menten type metabolism, Animal scale-up




本文は、編集委員会の意向によりインターネットには公開しておりません。図書館等でご覧ください。

Texts are not availavle on Internet.



目次・Contentsに戻る