山梨医科大学雑誌　第6巻4号　183-191(1991)

Assessment of Plasma Protein S Functional Activity and Antigen in
Patients with Liver Cirrhosis

Isao KOBAYASHI, Satomi HAMAOKA, Norihiko AMEMIYA, Takeshi ENDO, Kohji TAMURA,
Shoji KUME, Kenji AKABANE, and Hiroshi SUZUKI

Abstract: Protein S functional activity, free and total protein S antigen as well as C4b binding protein antigen were assayed in patients with liver cirrhosis and the amounts of free protein S and protein S bound to C4b binding protbin in normal subjects and in patients with liver cirrhosis were also calculated from the area of two-dimensional immunoelectrophoresis. Cholinesterase activity correlated well with total protein S, C4b binding protein and protein S bound to C4b binding protein but not with the functional activity of protein S nor with free protein S antigen. The ratio of free protein S to protein S bound to C4b binding protein was 68±3%; in normal subjects and 127±69% in patients with liver cirrhosis. C4b binding protein had an inverse correlation with the ratio of free protein S to protein S bound to C4b binding protein. From these data, we can conclude that protein S bound to C4b binding protein but not free protein S reflects the level of liver function of macromolecular synthesis in liver cirrhosis and that the binding condition between C4b binding protein and protein S in patients with liver cirrhosis is different from that in normal subjects.

Key words: Protein S functional activity, Total and free protein S antigen, Protein S bound to C4b binding protein, C4b binding protein, Liver cirrhosis




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