山梨医科大学雑誌　第7巻2号　035-041(1992)

Tyrosine Kinase and Platelet Functions

Yukio OZAKI

Abstract: Tyrosine protein kinases that phosphorylate substrate proteins at the tyrosine residues are abundant in human platelets. The major component of tyrosine kinase is attributed to pp60c-src which is a protooncogene product. Upon stimulation of platelets, several sets of tyrosine-phosphorylated proteins are expressed, the type and time course of which vary with different agonists employed. The tyrosine kinase activity may be closely associated with the activation of the fibrinogen-binding glycoprotein IIb/IIIa, intracellular Ca++ mobilization, and inositol phosphofipid metabolism.

Key words: Platelet, Tyrosine kinase, Tyrosine phosphorylation, Genistein




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