山梨医科大学雑誌　第8巻1号　001-008(1993)

＜総説＞小児 Biphenotypic leukemia の分類の試み

中澤眞平，杉田完爾，犬飼岳史，斎藤みどり，
杉泰二郎，西野和良，鈴木敏雄，木下明俊，
高根恵子，岡崎敏子




Immunophenotypic Classification of Childhood Biphenotypic Leukemia

Shinpei Nakazawa, Kanji Sugita, Takeshi Inukai, Midori Saito, Taijiro Mori,
Kazuyoshi Nishino, Toshio Suzuki, Akitoshi Kinoshita, Keiko Takane,
and Toshiko Okazaki

Seven hundred and forty-five newly diagnosed patients with acute leukemias between 1978 and 1990 were classified on the basis of immunological phenotype. The incidence of subclassification of acute leukemias in this study was as follows: 522 patients with ALL (70%), 139 patiens with ANLL (18%), 29 patients with biphenotypic leukemia, 8 patients with Ph1-positive acute leukemia, and 46 patients with infantile leukemia. ALLs were classified into common ALL (77%), T-ALL (15%), B-ALL (4%), and unclassified ALL (3%). Biphenotypic leukemias were categorized into 4 groups as follows; 1) common ALL with positive myelomonocytic antigen(s) (N=11), 2) unclassified ALL with positive myelomonocytic antigen(s) (N=5), 3) ANLL with positive B-lymphoid antigen(s) (N=4) and 4) acute leukemia with positive T-lymphoid and myeloid antigen(s). Among these 4 groups of biphenotypic leukemia, groups 2 and 4 disclosed a poor prognosis as was reported in infantile leukemia and Ph1-positive acute leukemia. Many questions regarding the biological and clinical aspects of biphenotypic leukemias stiil remain to be solved, but the precise and detailed sutailed subclassifications of acute leukemias will establish an appropriete strategy of therapy.

Key words: biphenotypic leukemia, acute mixed lineage leukemia.



本文は、編集委員会の意向によりインターネットには公開しておりません。図書館等でご覧ください。

Texts are not availavle on Internet.



目次・Contentsに戻る