山梨医科大学雑誌　第8巻1号　009-013(1993)

Effects of Static Magnetic Fields on the Induction of Sister Chromatid
Exchange in Human Lymphocytes in vitro

Sumio IIJIMA, Zentaro YAMAGATA, Toshimi 0OMA, Tatsuya TAKESHITA,
Makoto HIGURASHI, and Akio ASAKA

Abstract: The effects of static magnetic fields (MF) on the induction of sister chromatid exchange (SCE) were examined in human lymphocytes using whole blood culture. The SCE frequency in the group unexposed to MF was 9.23±0.08. In the groups exposed to 0.4 and 0.8 T of MF, the SCE frequency was 9.88±0.38, 8.93±0.64, respectively. There were no significant differences between unexposed and exposed groups. Analysis of the cell cycle kinetics revealed no marked differences between unexposed and exposed groups.
The SCE frequency increased dose-dependently by the treatment with the known mutagen ethylmethanesulfonate (EMS), there being no significant difference between MF exposed and unexposed groups. There was also no difference between MF-exposed and MF-unexposed groups in the SCE frequency in the control group without EMS. These findings were in good accordance with the previous reports and suggest that static MF could not induce SCE.

Key words: Magnetic fields, Sister chrornatid exchange (SCE), Human lymphocyte, Ethylmethanesulfonate (EMS), Cell cycle kinetics




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