山梨医科大学雑誌　第8巻2号　057-063(1993)

A Case of Giant Undifferentiated Sarcoma of the Liver with Marked Regression after Transarterial Chemoembolization

Hiroshi NAKAGOMI, Masatoshi MOGAKI, Masaru IWASAKI, Kunio TAKANO, Kohzou KOSHIZUKA,
Hiroshi OHSAWA, Tomoo MIYAKE, Tetsunosuke MATSUKAWA, Takaya NAKANE,
Toshitugu YAMORI, Akira SHIMIZU, Masatoshi MAKUUCHI,
and Akira UENO

Abstract: Presented in this paper is a case of undifferentiated sarcoma of the liver (USL), especially for its therapy and angiographic findings. The patient, a 13-year-old girl was referred to our institute for a large low density mass of the liver revealed by computed tomography. The tumor occupied whole of the anterior and the medial segments of the liver. Angiographic evidence revealed elongation and stricture of the left branch of the portal vein. In addition, the occluded inferior vena cava (IVC) and development of intrahepatic collateral circulation between IVC and hepatic vein were seen. Based on these findings, we initially considered the tumor nonresectable and chose transarterial chemotherapy through the hepatic artery. Chemoembolization using the emulsion of Cisplatin (with the dose of 100 mg) and Lipiodol (5 ml) showed remarkable effects and allowed us to perform extended right trisegmentectomy of the liver.
Pathological examination of surgical specimen provided a diagnosis of USL.
However, the patient died of local recurrence 7 months after operation and the autopsy revealed no distant metastasis. This fact suggested a complete resection was the only way to cure this disease.

Key words: Undifferentiated sarcoma of the liver, Chemoembolization of Cisplatin and Lipiodol




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