山梨医科大学雑誌　第9巻3号　105-114(1994)

High Serum Level of Macrophage Colony-Stimulating Factor (M-CSF) in lpr and gld Autoimmune Mice

Kachio TASAKA, Katsuo YOSHIDA, Mubeo YAMADA, Nobuya YANAI,
and Yasuo NAKAJIMA

Abstract: In order to study the pathogenesis of autoimmune disease, serum M-CSF levels were measured by soft agar method in autoimmune MRL/lpr, BXSB, C3H/lpr, C3H/gld, NZB/W F1 mice as well as control MRL/n, C3H/Hej, BALB/c mice. Circulating levels of M-CSF were higher in MRL/lpr, C3H/lpr and C3H/gld mice than control mice, indicating the contribution of the lpr and gld genes. The number of macrophage precursor cell in the spleen was also higher in MRD/lpr, mouse than MRL/n mouse. However, there were no differences in Ia-positive macrophages from the bone marrow or spleen between high M-CSF group and low M-CSF group.

Key words: M-CSF, Mouse, Autoimmune, lpr, gld




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