山梨大学看護学会誌　第4巻1号　003-007(2005)

＜総説＞
外因性性ホルモン・内分泌撹乱物質と性分化異常

大山 建司

　母体に投与された性ホルモン製剤が胎児の性分化に影響することは知られているが，ホルモン作用を有する内分泌撹乱物質などの胎児への影響は様々な報告が交錯し，一定の見解が得られていないのが現状である。性分化への外因性性ホルモン，内分泌撹乱物質の影響に関するこれまでの報告の概略を示し，今後に向けての問題点を述べる。

キーワード:内分泌撹乱物質，性分化異常，性ホルモン，催奇形性



Disorders of Sex Differentiation Caused by Exogenous Sex Hormones
and Endocrine Disruptors

OHYAMA Kenji

　Transplacental and lactogenic exposure of fetus and neonate to exogenous sex hormones and endocrine disrupters can cause a range of abnormalities of the reproductive system including sex differentiation and sex maturation. Sex differentiation is critically dependent on the normal action of androgens and can be disturbed by unbalanced androgen/estrogen action. Androgenic substances masculinize female fetus. Progestogens act both as androgen antagonists, demasculinizing males, and as androgen agonists, masculinizing females. Transplacental exposure of male fetus to diethylstilbestrol is recognized to have led to increases in the incidence of cryptorchidism, hypospadia and decreased sperm counts. A growing number of endocrine disrupters have been found to possess either weak estrogenic, anti-androgenic or other hormonal activities. Increased exposure to environmental endocrine disr upters can cause male pseudohermaphroditism.

keywords: Endocrine Disruptors, Disorders of Sex Differentiation Sex Hormones, Teratogenicity


論文PDFファイル (92KB) はここをクリックしてください Full Text PDF File (92KB)



目次・Contentsに戻る