山梨医科大学紀要　第12巻，018-022(1995)

Recurrence Pattern of Hepatocellular Carcinoma after Curative Resection

Kaoru NAGAHORI, Masanori MATSUDA, Yoshiro MATSUMOTO

　Even after curative operation for small hepatocellular carcinoma (HCC) the postoperative intrahepatic recurrence rate is still high. In this study we analyzed the recurrence pattern of l06 patients who underwent curative primary resection between October,1983 and December,1994 in our hospital. While the cumulative survival rates 2 and 5 years after the operation were 82 and 64 %, respectively, the corresponding cumulative disease-free survival rates after the operation were 56 and 64 %, respectively. Recurrence was seen in 45 patients. Among 41 patients with intrahepatic recurrence, one to three nodules in the same lobe as the primary tumor were seen in 9, those in a different lobe in 12, multiple nodules in 18 and marginal recurrences in 2. In 29 patients whose recurrent HCC were analyzed for clonality, 14 showed metachronous multicentric(MC) HCC and 10 metastatic HCC. Repeat resection was performed in 10 patients with the form of one to three nodular recurrence and in 8 the recurrences were MC. The survival rate after the re-operation was the same as that after the first resection.lt seems important to detect MC in the early stage after the first operation and perform radical treatments in order to prolong the survival.

Key words : Hepatocellular carcinoma, Postoperative recurrence, Treatments, Multicentric occurrence



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