山梨医科大学紀要　第13巻，013-017(1996)

河野,浩二/関川,敬義/松本,由朗




Alterations in Signal Transducing Molecules on T-cells in Cancer Patients.
- Decreased CD 3ζ Chain on T Cells in Cancer Patients -

Koji KONO, Takayoshi SEKIKAWA and Yoshirou MATSUMOTO

　Recent evidence suggests that T cells in cancer patients exhibit abnormalities in signal transduction that related to unresponsiveness to appropriate activation signals. Here we review the evidence that the expression of CD 3ζ molecules were reduced in tumor-bearing host, and discuss the mechanism behind these alteration.

key word : CD 3ζ, T cell, cancer


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